Welcome to the Lakshman research laboratories
The research conducted in our laboratories involves organic chemical synthesis, particularly pertaining to questions of biological interest. The program has many facets but can be broadly divided into the following areas. The links shown to the left provide listings of publications on the specific topics as well as other information.
Catalysis Chemistry. This area involves the development of metal-mediated methods, primarily for nucleoside modification and also for the modification of other molecules of biological interest. Metal-catalyzed processes that have been studied so far involve palladium, copper, and ruthenium. Also of interest is the development and study of new catalytic systems. Via collaborations, we have begun to use some computational methods in this area.
Nucleoside Modification Chemistry. This area overlaps with our interests in catalysis chemistry as well as the chemistry and biology of polycyclic aromatic hydrocarbons. Additionally, we are also developing uncatalyzed methods for nucleoside modification. In this context we have been exploring unusual reactions of peptide coupling agents for transformations that have not previously been studied. Some of the chemical developments herein contribute to the generation of new synthetic methodology as well.
Polycyclic Aromatic Hydrocarbon Chemistry. There are numerous aspects in this field that we are involved with. For example, in one direction we are developing diastereoselective syntheses of polycyclic aromatic hydrocarbon derivatives, which when conjugated with appropriate reactive nucleosides, then lead to stereochemically-defined nucleoside adducts. Such adducts can then be appropriately functionalized and incorporated into short DNA fragments. These DNA then serve as probes of structure and biological function. Another avenue of investigation is the development of novel synthetic methodology for synthesis of functionalized, non-planar hydrocarbons for probing questions on metabolism. In this aspect we have also been using computational methodology, X-ray crystallography, and biological experiments, via collaborations.
Synthetic Methodology. A broadly encompassing theme of our research is the development, mechanistic understanding, and general utility of the chemical methodologies developed. Some examples of new chemical methodology are our studies on the use of diboron reagents for deoxygenation, cycloaddition reactions of the reactive arynes, and investigations into the unusual reactions of peptide coupling agents.
Please also see this link for updated list of publications: http://www.ccny.cuny.edu/profiles/Mahesh-Lakshman.cfm
Cover features of our articles (designed by Mr. Satish Lakshman)
Contact: mlakshman[ at ]ccny.cuny.edu
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