Electron transfer & proton transfer reactions. Evaluating when and where electrostatic interactions are important in proteins.
• Using time-resolved optical spectroscopy to study photosynthetic reaction centers. The aim is to characterize the energy landscape (reaction barriers and thermodynamics) of electron transfer reactions that are coupled to protein and proton motions.
• Calculating pKs and electrochemical midpoints in proteins to see how a protein's form yields its function.
• Developing MCCE which combines continuum electrostatics & molecular mechanics to study coupled conformation & ionization state changes in proteins.
MCCE Download MCCE executable for LINUX or Mac OSX
or use database of 35,000 calculated pKs from 500 proteins
Teaching: updates for students
Phusics 422 and Physics 732 Biophysics
Physics 315 Medical Physics