Ranajeet Ghose
Assistant Professor
Biophysical Chemistry
Tel: (212) 650-6049 (office), (212) 650-6513 (laboratory)
Fax: (212) 650-6107
Email:rghose@sci.ccny.cuny.edu
URL:http://www.sci.ccny.cuny.edu/~ghose/welcome.htm
B. Sc. (Hons.) Presidency College, Calcutta,
M. Sc. Indian Institute of Technology, Kanpur,
M. S., Ph. D. Yale University
Research
From bacteria to humans, the life-cycle of a species depends on an delicately-balanced network of protein-protein interactions in space and time. We investigate a small subset of these interactions using a host of biophysical and biochemical techniques including solution-state nuclear magnetic resonance (NMR) methodology and X-Ray crystallography.
Our current research topics include:
Intracellular signalling involving prokaryotic and eukaryotic tyrosine kinases.
Structure and organization of the RNA polymerase complex in cystoviruses.
Development of novel NMR methods to study correlated dynamics on multiple timescales in proteins.
Development of NMR methods to obtain structural constraints in large proteins/complexes.
Selected Publications
Eryilmaz E, Benach J, Su M, Seetharaman J, Dutta K, Wei H, Gottlieb P, Hunt JF and Ghose R 2008. Structure and Dynamics of the P7 Protein from the Bacteriophage f12. J. Mol. Biol. 382, 402-422.
Ferrage F, Piserchio A, Cowburn D and Ghose R 2008. On the Measurement of 15N-{1H} Nuclear Overhauser Effects. J. Magn. Reson. 192, 302-313.
Del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia I and Ghose R. 2007. Solution Structure and Dynamics of the N-terminal Cytosolic Domain of Rhomboid Intramembrane Protease from Pseudomonas aeruginosa: Insights into a Functional Role in Intramembrane Proteolysis. J. Mol. Biol. 365, 109-122.
Del Rio A, Anand A and Ghose R 2006. Detection of Correlated Dynamics on Multiple Timescales by Measurement of the Differential Relaxation of Zero- and Double-Quantum Coherences Involving Sidechain Methyl Groups in Proteins. J. Magn. Reson. 180, 1-17.
Dutta K, Shi HH, Cruz-Chu ER, Kami K and Ghose R 2004. Dynamic influences on a high-affinity, high-specificity interaction involving the C-terminal SH3 domain of p67phox. Biochemistry 43, 8094-8106.
Majumdar A and Ghose R 2004. Probing slow backbone dynamics in proteins using TROSY-based experiments to detect cross-correlated time-modulation of isotropic chemical shifts. J. Biomol. NMR 28, 213-227.
