Publications

Selected Publications

Schinkmann K, Li C (1992) Localization of FMRFamide-like peptides in Caenorhabditis elegans.  J Comp Neurol 316:251-260.

Rosoff M, Bürglin T, Li C (1992) Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans.  J Neurosci 12:2356-2361.

Rosoff M, Doble K, Price DA, Li C (1993) The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans.  Peptides 14:331-338.

Daigle I, Li C (1993) apl-1, a C. elegans gene encoding a protein related to the human b-amyloid protein precursor.  Proc Natl Acad Sci USA 90:12045-12049.

Nelson L, Kim K, Memmott J, Li C (1998) FMRFamide-related gene family in the nematode Caenorhabditis elegans.  Mol Br Res 58:103-111.

Nelson L, Rosoff ML, Li C (1998) Disruption of a neuropeptide gene, flp-1, causes multiple behavioral phenotypes in C. elegans.  Science 281:1686-1690.

Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M (2003) Inhibition of social feeding in C. elegans by FMRFamide-related peptide activation of the NPR-1 receptor.  Nature Neurosci 6:1178-1185.

Lints R, Jia L, Kim K, Li C, Emmons SW (2004) Axial patterning of C. elegans male sensilla identities by selector genes.  Dev Biol 269:137-151.

Kim K, Li C (2004) Expression and regulation of a FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.  J Comp Neurol  475:540-550.

Zhao J, Townsend KL, Schulz LC, Kunz TH, Li C, Widmaier EP (2004) Leptin receptor expression increases in placenta, but not hypothalamus, during gestation in Mus musculus and Myotis lucifugus.  Placenta J 25:712-722.

Shan G, Kim K, Li C, Walthall WW (2005) Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans.  Dev Biol 280: 494-503.

Novillo A, Won S-J, Li, C, Callard IP (2005) Changes in nuclear receptor and vitellogenin gene expression in response to steroids and heavy metal in Caenorhabditis elegans.  Integr Comp Biol 45:61-71.

Hornsten A, Lieberthal J, Fadia S, Malins R, Ha L, Xu X, Daigle I, Markowitz M, O’Connor G, Plasterk R, Li C (2007) APL-1, a C. elegans protein related to human Amyloid Precursor Protein, is essential for viability.  Proc Natl Acad Sci USA 104:1971-1976.  Selected as an Editors’ Choice Science 315:914 (2007)

Liu T, Kim K, Li C, Barr M (2007) FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.  J Neurosci 27:7174-7182.

Niwa R, Zhou F, Li C, Slack F (2008) The expression of the Alzheimer’s amyloid precursor protein-like gene is regulated by developmental timing using microRNAs and their targets in Caenorhabditis elegans.  Dev Biol 315:418-425.

Seid M, Goode K, Li C, Traniello J (2008) Age- and subcaste -related patterns of serotonergic immunoreactivity in the optic lobes of the ant Pheidole dentata.  Develop Neurobiol 68:1325-1333.

Hoopes JT, Liu X, Xu X, Demeier B, Folta-Stognlew E, Li E, Ha Y (2010) Structural characterization of the E2 domain of APL-1, a C. elegans homolog of human amyloid precursor protein, and its heparin binding site.  J Biol Chem 285:2165-2173.

Dimitriadi, M., J.N. Sleigh, A.K. Walker, H.C.-H. Chang, A. Sen, G. Kalloo, J. Harris, T. Barsby, M.B. Walsh, J.S. Satterlee, C. Li, D. Van Vactor, S. Artavanis-Tsakonas, and A. Hart (2010) Conserved genes act as modifiers of invertebrate SMN loss of function defects.  PLoS Genetics 6(10): e1001172. doi:10.1371/journal.pgen.1001172.

Arimoto M,  Koushika S, Choudhary B, Li C, Matsumoto K, Hisamoto N (2011) The C. elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein.  J Neurosc 31:2216-2224.

Cha DS, Hollis SE, Datia US, Lee S, Ryu J, Jung HR, Kim E, Kim K, Lee M, Li C, Lee MH (2012) Differential subcellular localization of DNA topoisomerase-1 isoforms and their roles during Caenorhabditis elegans development.  Gene Expression Patterns 12:189-195.

Ewald CY, Raps DA, Li C (2012) APL-1, the Alzheimer’s amyloid precursor protein in Caenorhabditis elegans modulates multiple metabolic pathways throughout development.  Genetics 191: 493-507.

Ewald  CY, Cheng R, Tolen L, Shah V, Gillani A, Nasrin A, Li C (2012) Pan-neuronal expression of APL-1, an APP-related protein, disrupts olfactory, gustatory, and touch plasticity in C. elegans.  J. Neurosci. 32:10156-10169.

Li C, Timbers TA, Rose JK, Bozorgmehr T, McEwan A, Rankin CR (2013) The FMRFamide-related neuropeptide FLP-20 is required in the mechanosensory neurons during memory for massed training in C. elegans.  Learning and Memory 16:103-108.

Kim J, Yeon J, Choi S-K, Huh YH, Fang Z, Park SJ, Kim MO, Ryoo ZY, Kang K, Kweon H-S, Joon WB, Li, C, Kim K (2015) The evolutionarily conserved LIM homeodomain protein LIM-4/LHX6 specifies the terminal identity of a cholingeric and peptidergic C. elegans sensory/inter/motor neuron-type.  PLoS Genetics, in press.

Chang Y-J, Burton T, Ha L, Huang Z, Olajubelo A, C Li (2015) Modulation of locomotion and reproduction by FLP neuropeptides in the nematode Caenorhabditis elegans.  PLoS ONE, accepted.

Book chapters and reviews

Li C (2005) The ever expanding neuropeptide gene families in the nematode Caenorhabditis elegans. Parasitology 131:S109-127.

Li C, Kim K (2007) Neuropeptide gene families in Caenorhabditis elegans. In Neuropeptide Systems as Targets for Parasite and Pest Control, http://www.eurekah.com/chapter/3715.

Li C, Kim K (2008) Neuropeptides in C. elegans. In WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.142.1, http://www.wormbook.org

Ewald CY, Li C (2010) Understanding the molecular basis of Alzheimer’s disease using a Caenorhabditis elegans model system. Brain Structure & Function 214:263-283.

Li C, Kim K(2010) Neuropeptide gene families in Caenorhabditis elegans. In Neuropeptide Systems as Targets for Parasite and Pest Control, Adv. Exp. Med. Biol. 692:98-137.

Ewald CY, Li C (2012) Caenorhabditis elegans as a model organism to study APP function.  Experimental Brain Research 217:397-411.

Ewald CY, Li C (2012) The secreted Alzheimer-related amyloid precursor protein fragment has an essential role in C. elegans.  Prion 6:1-4.

Alexander A, Marfil V, Li C (2014) Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative disorders. Front Genet Sep 5;5:279. doi: 10.3389/fgene.2014.00279. eCollection 2014.

Li C, Kim K (2014) Family of FLP peptides in Caenorhabditis elegans and related nematodes.  Front Endocrinol Oct 14;5:150. doi: 10.3389/fendo.2014.00150. eCollection 2014.

Primer Information or Raw Data from publications

Primer list (excel spreadsheet) from Kim K, Li C (2004) Expression and regulation of a FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.  J Comp Neurol  475:540-550.flpGFP constructsflpGFP constructs

Raw data (Prism files) from Chang Y-J, Burton T, Ha L, Huang Z, Olajubelo A, C Li (2015) Modulation of locomotion and reproduction by FLP neuropeptides in the nematode Caenorhabditis elegans.  PLoS ONE, accepted.M9Swimming Assay5-HTSwimmingegg laying ratesegg retention