THOMAS H

THOMAS H. HAINES

2/2002

Professor of Chemistry and Biochemistry, City College of CUNY

Director of Biochemistry, Sophie Davis School for Biomedical Education/CUNY Medical School

Date of Birth: August 9, 1933

Place of Birth: New York, NY USA

EDUCATION

Institution Degree Year

City College of CUNY B. S. 1957

City College of CUNY M. S. 1959

Rutgers the State University Ph. D. 1964

MAJOR RESEARCH INTERESTS: Biochemistry, Biophysics, Membranes and Cell Biology; Why membrane lipids are designed the way they are.

HONORS

Honors Fellowship, Rutgers the State University (1963).

NSF-NIH Joint Travel Award to Tokyo, Japan to attend IUB Conference, (1967) (ASBMB Award).

NATO Senior Fellow: Awarded by the National Science Foundation, (1970).

Invited by the USSR Academy of Sciences to chair the first symposium on Lipids ever held at a IUPAC Conference; Riga, USSR, (1970).

Co-Chairman; Symposium on Lipids and Monolayers, Amer. Oil Chem. Soc., New York, NY, (1970).

Chairman; Symposium on Sulfolipids, American Oil Chemists Society, Houston, TX, (1970).

Elected to the American Society of Biological Chemists (1970)

125th Anniversary Medal, City College of CUNY, (1972).

Member, Medical advisory Committee, Sophie Davis School for Biomedical Education,. Other members included all of the Deans of New York’s Medical Schools. (1974-78).

Member, American Society of Biological Chemists, Education Committee, (1986-1991)

Chair, Symposium on Membrane Dynamics, The Biophysical Society, Phoenix, AZ (1988)

Chair, Biophysics Section, New York Academy of Science (1991-1993).

Member, Association of Graduate and Medical Schools Biochemistry Chairs, (1986-pres.)

Honored Professor Award; CUNY Medical School; (1982, 1983, 1986, 1988, 1989, 1992, 1993, 1995).

Twentieth Anniversary Medal, for establishing the CUNY Medical School, (1993).

Biochemistry and Cell Biology Study Section of NIH Institute for Alcoholism and Alcohol Abuse, 1992-95

Chaired Symposium, "Should a Year of Organic Chemistry be Required for Medical School Admission?", ASBMB/ACS Joint Meeting, San Francisco, CA, (1995).

MEMBERSHIPS

American Association for the Advancement of Science, American Chemical Society, American Oil Chemists Society, American Society of Biochemists and Molecular Biologists, Biophysical Society, New York Academy of Sciences.

AD HOC REVIEWER

Journals: Archives Biochemistry and Biophysics, Biochem. J., Biochemistry, Biochimica Biophysica Acta, Comp. Biochem. Physiol., European J. Biochem. FEBS Letters, J. American Chemical Society, J. American Oil Chemists Society, J. Bacteriol., J. Biological Chemistry, J. Biochem. (Tokyo), J. Colloid Research, J. of Investigative Dermatology, J. Lipid Research, J. Membrane Biology, J. Natural Products Chemistry, J. Physical Chemistry, J. Protozoology, J. Theoretical Biology, Lipids, Proceedings National Academy of Sciences, Science, and Virology.

Reviewing Service for Granting Agencies: Department of Agriculture, Department of Energy, National Institute Environmental and Health Sciences, National Science Foundation, National Institutes of Health, National Institute for Alcohol and Alcoholism, The Petroleum Research Fund, and several University funding programs (Guelph, CUNY, etc.)

RESEARCH AND PROFESSIONAL EXPERIENCE

Professor of Biochemistry, Doctoral Program of Biochemistry, Graduate Center, CUNY, (1972-pres.)

Professor of Chemistry, City College of CUNY, (1972-pres.)

Director of Biochemistry, CUNY Medical School, (1974-pres.)

Principal Investigator of Research Grants from National Institutes of Health, National Science Foundation,

National Heart Institute, Petroleum Research Fund, CUNY Faculty Research Award Program, Commonwealth Fund, Mellon Foundation, (1970-pres.)

Visiting Scholar, Dept. of Cell and Molecular Biology, Div. Biochem., U. Cal., Berkeley, CA, (1993-4).

Recipient, 20^th Anniversary Medal from the Sophie Davis School for Biomedical Education, Hilton Hotel, New York. March (1994).

Visiting Scholar, Mitsubishi-Kasai Institute for Life Sciences, Tokyo Japan, (1986-1987).

Visiting Professor, Beijing Medical School, Beijing, China, (1986).

Visiting Professor, University of Minnesota, The Hormel Institute, Austin MN Spring (1978).

Acting Director, Center for Biomedical Education. Established a 6-Year MD program. (1972-74)

Visiting Associate Professor, University of California, Berkeley, (1970-71).

Visiting Scholar, National Center for Scientific Research (C.N.R.S,) Institute for the Chemistry of Natural Products, Gif-sur-Yvette, France, (1970).

NATO Senior Fellow, NSF Award, (1970).

Lecturer, Department of Chemistry, City College of City University of New York (1963-64)

Research Assistant, Department of Biochemistry, Rutgers the State University, (1962-63).

Research Biochemist, Boyce Thompson Institute for Plant Research, Yonkers, NY (1959-62).

Science Teacher Fieldston School, Riverdale, NY (1958-59).

Research Assistant, School of Education, CCNY, (1957-58).

PROFESSIONAL ACTIVITIES (Other than academic appointments)

President of the City College Science Alumni Association. 1998 to Present.

Chair of the Biophysics Section of the New York Academy of Sciences. 1991-1993.

Member of the Executive Committee of the Levich Institute for Hydrodynamics, City College of CUNY. 1991 to present.

Member of the Board of Directors of the Alumni Association of CCNY. 1991 to present.

Member of the Education Committee of the American Society of Biochemists and Molecular Biologists. 1993-1995.

Consultant, Liposome Technology Incorporated, (1993-4).

Consultant, Sequus, Inc.(1995-Pres.)

Appointed Ad Hoc Member, NIAAA Biochemistry and Cell Biology Study Section, National Institute of Alcoholism and Alcohol Abuse for the review of grant proposals, Bethesda MD 1994-1997.

President of the City College Chemistry Alumni Association. 1993-1998.

Chair Symposium on Membrane Dynamics. Biophysical Society, Phoenix, AZ March 1988.

Chair Symposium on Sulfolipids, American Oil Chemists Society, Houston TX October 1971.

Co-Chair Symposium on Lipids and Monolayers, American Oil Chemists Society, NY, NY, May 1970.

Invited by the Soviet Academy of Sciences to Chair the first symposium ever held on lipid chemistry at a IUPAC Conference, Riga, USSR June 1970.

PUBLICATIONS

BOOK

Haines, T. H. (1972) The Sulfolipids. In series: Progress in the Chemistry of Fats and Oils. Series editor, Ralph Holman. Pergamon Press, NY.

REFEREED JOURNALS

Haines, T. H., S. M. Henry & R. Block. (1960) The sulfur medabolism of insects, V. The ability of insects to use sulfate in the synthesis of methionine. Contrib. Boyce Thompson Inst. 20, 363-5.

Haines, T. H. & R. Block. (1962) The sulfur metabolism of algae. I. Synthesis of metabolically inert chloform-soluble sulfate esters by two Chrysomonads and Chlorella pyrenoidosa. J. Protozool. 9, 33-38.

Haines, T. H., S. Aaronson, J. Gellerman & H. Schlenk. (1962) Occurrence of arachidonic acid and related acids in the protozoan, Ochromonas danica. Nature 194, 1283-4.

Aaronson, S., B. Bensky, T. H. Haines, J. Gellerman & H. Schlenk. (1963) Fatty acids of protozoa, especially of phytoflagellates; differences associated with the absence of photosynthetic apparatus in Euglena. J. Protozool. 10, 9-12.

Haines, T. H. A microbial sulfolipid. I. Isolation and physiological studies. (1965) J. Protozool. 12, 656-659.

Mayers, G.L. & Haines, T.H. (1967). A microbial sulfolipid. II. Structural studies. Biochemistry 6, 1665-1671.

Haines, T. H. (1967) A new sulfolipid. Application to problems of drug transport. Progr. In Biochemical Pharmacology, Vol. III, 1848-54.

Gershengorn, M. C., A. R. H. Smith, G. Goulston, L. J. Goad, T. W. Goodwin & T. H. Haines. (1968) The sterols of Ochromonas danica and O. malhamensis. Biochemistry 7, 1698-1708.

Haines, T.H., Pousada, M., Stern, B., and Mayers, G.L. (1969). Microbial sulpholipids. IV. (R)-13-choro-1-(R)-14-docosanediol disulphate and polychlorosulpholipids in Ochromonas danica. Biochem. J. 113, 565-566.

Mayers, G.L., Pousada, M., & Haines, T.H. (1969). Microbial sulfolipids. 3. The disulfate of (+)-1,14-docosanediol in Ochromonas danica. Biochemistry 8, 2981-2986.

Haines, T. H. (1970) The reduction of alkyl sulfates to alkane with lithium aluminum hydride. Lipids 5, 149-151.

Haines, T. H. (1970) Algae sulfolipids and chlorosulfolipids. In, "Properties and Products of Algae." J. E. Zajic, ed. New York Plenum Press, pp. 129-142.

Aaronson, S., U. Behrens, R. Orner & T. H. Haines. (1971) Ultrastructure of intracellular and extracellular vesicles, membranes and myelin figures produced by Ochromonas danica. J. Ultrastructure Research 35, 418-30.

Mooney, C. L., E. M. Mahoney, M. Pusada & T. H. Haines. (1972) Direct incorporation of fatty acids into the halosulfatides of Ochromonas danica. Biochemistry 11, 4839-44.

Haines, T.H. (1973). Halogen- and sulfur-containing lipids in protozoa.. Annu. Rev. Microbiol. 27, 403-411.

Mooney, C. L. & T. H. Haines (1973) Chlorination and sulfation reactions in the biosynthesis of chlorosulfolipids in Ochromonas danica, in vivo. Biochemistry 12,4469-72.

Haines, T. H. (1973) Sulfolipids and halosulfolipids. In, "Lipids and Biomembranes of Eukaryotic Microorganisms." Ed., J. A. Erwin, Academic Press, NY.

Haines, T. H. (1974) The halogenated sulfatides. In, "Biochemistry of Lipids." In MTP International Review of Science , Biochemistry Vol. IV, T. W. Goodwin. Ed. Pp.271-286. Butterworths Press, Oxford.

Chen, L.L. & Haines, T.H. (1976). The flagellar membrane of Ochromonas danica. Isolation and electrophoretic analysis of the flagellar membrane, axonemes, and mastigonemes. J. Biol. Chem. 251, 1828-1834.

Chen, L.L., Pousada, M., & Haines, T.H. (1976). The flagellar membrane of Ochromonas danica. Lipid composition. J. Biol. Chem. 251, 1835-1842.

Haines, T.H. (1979). A proposal on the function of unsaturated fatty acids and ionic lipids: the role of potential compaction in biological membranes. J. Theor. Biol. 80, 307-323.

Haines, T. H. (1982) A model for transition state dynamics in bilayers. Implications for the role of lipids in biomembrane transport. Biophys. J. 37, 147-9.

Haines, T.H. (1983). Anionic lipid headgroups as a proton-conducting pathway along the surface of membranes: a hypothesis. Proc. Natl. Acad. Sci. U. S. A. 80, 160-164.

Haines, T. H. (1984) The microbial sulfolipids. CRC Handbook of Microbiology. Second Edition. Vol. V. A. I. Laskin & H. A. Lechevalier, eds. Boca Raton, FL 115-123.

Aurora, T.S., Li, W., Cummins, H.Z., & Haines, T.H. (1985). Preparation and characterization of monodisperse unilamellar phospholipid vesicles with selected diameters from 3000 to 6000 Angstroms. Biochim. Biophys. Acta 820, 250-258.

Li, W., Aurora, T.S., Haines, T.H., & Cummins, H.Z. (1986). The elasticity of synthetic phospholipid vesicles and. submitochondrial particles during osmotic swelling. Biochemistry 25, 8220-8229.

Li, W. & Haines, T.H. (1986). Uniform preparations of large unilamellar vesicles containing anionic lipids. Biochemistry 25, 7477-7483.

Haines, T.H., Li, W., Green, M., & Cummins, H.Z. (1987). The elasticity of uniform, unilamellar vesicles of acidic. Biochemistry 26, 5439-5447.

Rutkowski, C. R., Williams, L., Cummins, H. Z. & Haines, T. H. (1992) The elasticity of synthetic phospholipid vesicles obtained by photon correlation spectroscopy. Biochemistry 31, 5688-96.

Kates, M., Syz, J.Y., Gosser, D. & Haines, T.H. (1993). pH-dissociation characteristics of cardiolipin and its 2'-deoxy analogue. Lipids 28, 877-882.

Haines, T. H. (1994) Minireview. Water transport across biological membranes. FEBS Letters 346, 115-122.

Haines, T. H. & Liebovitch, L. (1995) A molecular mechanism for the transport of water across phospholipid bilayers. In "Permeability and Stability of Lipid Bilayers" S. A. Simon and A. Disalvo, eds. CRC Press, Boca Raton FL.

Mas-Oliva, J., Velasco-Loyden, G. & Haines, T. H. (1996) Receptor pattern formation as a signal for the capture of lipoproteins. Biochemical and Biophysical Research Communications 224, 212-218.

Haines, T. H. (2001) Do sterols reduce proton and sodium leaks through lipid bilayers? Progress in Lipid Research, 40, 299-324.

Mileykovskaya, E., Dowhan, W., Birke, R. L. Zheng, D. & Haines, T. H. (2001) Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces. FEBS Letters, 507, 187-190.

Hauß, T., Dante, S., Dencher, N. A.& Haines, T. H.(2002) The isoprene, squalane, lies in the center of the bilayer. Do isoprenes inhibit proton leaks across bilayers? Biochimica Biophysica Acta, 1556, 149-154.

T. H. Haines & N. A. Dencher (2002) Cardiolpin: a proton trap in oxidative phosphorylation. FEBS Letters 528, 35-39.