Mark R. Biscoe
Assistant Professor
Organic/Organometallic Chemistry
Email: mbiscoe[at]ccny.cuny.edu
Office: MR-1232
Lab: MR-1228
Research
Broadly, research in our lab focuses on catalysis. The two major types of
catalysis in which we are interested are transition metal catalysis and
macromolecular catalysis. Our primary goals involve the development of
practical, reliable, and environmentally-benign processes for the
construction of C-C and C-X (X = heteroatom) bonds.
Education
Wesleyan University (B.A. 1999)
Columbia University (Ph.D. 2005)
Massachusetts Institute of Technology (NIH Postdoctoral Fellow, 2005-2008)
Publications
12. Biscoe, Mark R.; Buchwald, Stephen L. "The Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides." Submitted.
11. Lee, Brian K.; Biscoe, Mark R.; Buchwald, Stephen L. "A Simple, Efficient Protocol for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine." Submitted.
10. Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; Buchwald, Stephen L. "A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines Using Aryl Chlorides." J. Am. Chem. Soc. 2008, 130, 13552-13554.
9. Biscoe, Mark R.; Fors, Brett P.; Buchwald, Stephen L. "A New Class of One-Component Pre-Catalysts for Facile C-N Cross-Coupling Reactions and Low Temperature Oxidative Addition of Aryl Chlorides." J. Am. Chem. Soc. 2008, 130, 6686-6687. [Featured as Editorbs Choice in: Science. 2008, 320, 850-851]
8. Biscoe, Mark R.; Barder, Timothy E.; Buchwald, Stephen L. "Electronic Effects on the Selectivity of Pd-Catalyzed C-N Bond-Forming Reactions Using Biarylphosphine Ligands: The Competitve Roles of Amine Binding and Acidity." Angew. Chem. Int. Ed. 2007, 46, 7232-7235.
7. Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. "Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation." J. Am. Chem. Soc. 2007, 129, 13001-13007.
6. Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. "Structural Insights into Active Catalyst Structures and Oxidative Addition to (Biaryl)phosphine-Palladium Complexes via Density Functional Theory and Experimental Studies." Organometallics 2007, 26, 2183-2192.
5. Uyeda, Christopher; Biscoe, Mark; Leplae, Paul; Breslow, Ronald. "Hydrophobically-Directed Selective Reduction of Ketones Using Amine Boranes." Tetrahedron Lett. 2006, 47, 127-130.
*4. Biscoe, Mark R.; Breslow, Ronald. "Oxaziridinium Salts as Hydrophobic Epoxidation Reagents: Remarkable Hydrophobically-Directed Selectivity in Olefin Epoxidation." J. Am. Chem. Soc. 2005, 127, 10812-10813.
*3. Biscoe, Mark R.; Uyeda, Christopher; Breslow, Ronald. "Requirements for Selective Hydrophobic Acceleration in the Reduction of Ketones." Org. Lett. 2004, 6, 4331-4334.
*2. Biscoe, Mark R.; Breslow, Ronald. "Hydrophobically-Directed Selective Reduction of Ketones." J. Am. Chem. Soc. 2003, 125, 12718-12719.
1. Biscoe, M. R.; Fry, A. J. "Dual Reaction Pathways in the Magnesium-Mediated Synthesis of Aziridines from Benzal Halides and Imines." Tetrahedron Lett. 2001, 42, 2759-2762.
* The work presented in publications 2-4 constitutes the major focus of a highlight article: Lindstrom, U. M.; Andersson, F. Angew. Chem. Int. Ed. 2006, 45, 548-551.